Disease Specific Animal Model Studies
An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of harming a human
Acute Toxicity Studies
Acute toxicity studies are conducted to determine the short-term adverse effects of a drug when administered in a single dose or in multiple doses during a period of 24 hours in two mammalian species (one non-rodent).
Sub-Acute Toxicity Studies
Subacute toxicity studies are conducted to evaluate a new drug's potential adverse effects following a treatment period of 2–4 weeks' duration. Sub acute toxicity studies are conducted as range-finding studies in order to choose dosage levels to be used in subsequent subchronic and chronic toxicity studies.
Sub Chronic and Chronic Toxicity Studies
Subchronic toxicity studies vary in length, typically ranging from 3 to 12 months, and are usually conducted in one rodent and one non-rodent species.
The purpose of chronic and subchronic toxicity study is to further test the hypotheses regarding mode of action, predict the health effects of your therapeutic entity in human exposure, identify target organs, further characterize the dose-response relationship, and identify a dose level that does not demonstrate adverse effects with chronic or subchronic use.”
Irritation Studies
The Irritation test(s) can be used to determine if a material or chemical will cause local irritation in the skin, mucosal, or ocular tissues. The test article extracts are dosed or the test article is directly applied to the animal.
Sensitization Studies
Skin sensitization testing identifies the potential for a substance to cause allergic contact dermatitis. Skin sensitization is a key endpoint for safety assessment, especially for chemicals in cosmetic and personal care products.
Reproductive toxicology
Reproductive toxicity tests assess a substance's tendency to cause reproductive system effects, while developmental toxicity testing evaluates the extent to which exposure to a substance may harm a developing embryo or fetus. Reproductive toxicology is the study of the occurrence, causes, manifestations, and adverse effects of exogenous agents on reproduction.
Carciogenecity Studies
The objective of carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test substance by an appropriate route of administration.
It determine the tumorigenic potential of medical devices, materials, and/or their extracts from either single or multiple exposures or contacts over a period of the major portion of the life span of the test animal.
Pyrogenecity